complement factor d — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T38332	Complement factor D-IN-2		Complement System
	Complement factor D-IN-2 is an inhibitor of Complement factor D and reduces the excessive activation of complement factor D.		Complement System
T16898	Complement factor D-IN-1		Others
	Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively).		Others
T8509	Danicopan	ACH-4471	Complement System
	Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the ...		Complement System
T39493	Vemircopan	ACH0145228,ACH-5228,ALXN2050
	Vemircopan is a complement factor D inhibitor.
T11269	FD-IN-1		Others
	FD-IN-1 is a factor D (FD) inhibitor with an IC50 of 12 nM.FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5μM, respectively. Complement FD, a highly specific S1 serine protease, plays a...		Others
T76814	Lampalizumab
	Lampalizumab (RG 7417), a humanized monoclonal antibody, selectively inhibits complement Factor D in the alternative complement pathway by binding to an exosite and sterically hindering Factor B's access to the active si...
T38803	Factor D inhibitor 6
	Factor D inhibitor 6 is a potent, highly selective, orally active compound that specifically inhibits the activity of factor D (FD). It demonstrates an IC50 of 30 nM and a Kd of 6 nM. Notably, Factor D inhibitor 6 does n...
T62020	Pelecopan
	Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D (IC50= 14.3 nM). Pelecopan can prevent both intravascular and extravascular hemolysis in PNH.
T77219	N-((Allyloxy)carbonyl)-N-methyl-L-alanine
	N-((Allyloxy)carbonyl)-N-methyl-L-alanine, an alanine derivative, serves as a precursor for the synthesis of complement factor D inhibitors, which are key in researching immune system-related diseases [1].

Compounds

Complement factor D-IN-2

T38332

Synonym:

Target: Complement System

Complement factor D-IN-1

Target: Complement System

Vemircopan

T39493

Synonym: ACH0145228,ACH-5228,ALXN2050

Factor D inhibitor 6

N-((Allyloxy)carbonyl)-N-methyl-L-alanine

T77219

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02167	Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293)	Mouse	HEK293 Cells
	Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.4 kDa and the accession number is P03953-2.
TMPY-02183	Complement Factor D/CFD Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Complement Factor D/CFD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.8 kDa and the accession number is P00746.
TMPJ-00149	Complement Factor D/CFD Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement a...
TMPH-03272	Complement factor D Protein, Rat, Recombinant (His)	Rat	P. pastoris (Yeast)
	Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classi...
TMPK-00151	Complement Factor D/CFD Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge...
TMPK-00755	Complement Factor D/CFD Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge...
TMPH-03271	Complement factor D Protein, Rat, Recombinant (His & Myc)	Rat	HEK293 Cells
	Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classi...
TMPK-00671	Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His)	Rhesus	HEK293 Cells
	Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge...
TMPH-02607	Complement factor B Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convert...
TMPH-03038	Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)	Naja kaouthia	E. coli
	Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to fo...